|
KMID : 0931320070070010026
|
|
대한상부위장관.헬리코박터학회지
2007 Volume.7 No. 1 p.26 ~ p.32
|
|
|
Effect of Helicobacter pylori Eradication on Healing of Iatrogenic Ulcer and Underlying Histology after Endoscopic Submucosal Dissection for Gastric Adenoma and Early Gastric Cancer
|
|
Cho Soo-Jeong
Kim Sang-Gyun
Im Jong-Pil
Kim Joo-Sung
Jung Hyun-Chae
Song In-Sung
|
|
|
Abstract
|
|
|
Background/Aims: A role of Helicobacter pylori (H. pylori) in the iatrogenic ulcer healing after endoscopic resection for gastric tumors is not clear. This study was conducted to elucidate the effect of H. pylori eradication on the healing of iatrogenic ulcer and underlying histology after endoscopic resection.
Methods: A total of 112 patients were prospectively enrolled after endoscopic submucosal dissection (ESD) between April 2005 and September 2006 and randomly assigned to either H. pylori eradication or follow-up group. Follow-up endoscopy was performed at 12 weeks after ESD to evaluate ulcer healing and histological change.
Results: H. pylori was eradicated in 45 patients, not eradicated in 63, respectively. The two groups were balanced statistically with respect to sex, age, ulcer size and complication rate. Follow-up endoscopy has revealed that all of the cases healed up to scar stages. Scores of neutrophil (p＜0.001) and mononuclear cell infiltration (p=0.048) improved in H. pylori eradicated group. However, atrophy (p=0.656) and intestinal metaplasia (p=0.752) showed no significant differences.
Conclusions: H. pylori eradication did not influence on ESD-induced iatrogenic ulcer healing as well as underlying atrophy or intestinal metaplasia. Long-term follow-up is warranted whether H. pylori eradication could reduce the risk of metachronous tumor development.
|
|
|
KEYWORD
|
|
|
Helicobacter pylori, Endoscopic submucosal dissection, Eradication, Ulcer healing, Gastric histology
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|